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Short Communication

Solid State Characterization and Dissolution Enhancement of Nevirapine Cocrystals

Prabhakar Panzade* ORCID logo, Giridhar Shendarkar, santosh shelke, Deepak Kulkarni

Abstract

Purpose: Novel cocrystals of nevirapine were designed and prepared with salicylamide and 3-hydroxy benzoic acid. Methods: The cocrystals were prepared by solvent drop grinding method by adding few drops of acetone to enhance the solubility and dissolution. The drug and cocrystals were characterized by differential scanning calorimetry and powder x-ray diffraction. The solubility of nevirapine, its wet ground form, and cocrystals was investigated at different pH. Moreover, the effect of surfactant on solubility of cocrystals was also studied. Finally, intrinsic dissolution rate and stability of cocrystals was examined. Results: The characterization of cocrystals by DSC and PXRD revealed formation of new solid forms. The cocrystals showed greater solubility in pH 1.2 buffer and in 1% tween 80 as compared to original drug. Intrinsic dissolution rate of cocrystals was higher than the pure drug in 0.1 N HCl (pH 1.2). Moreover, cocrystals were found physically stable after 3 months. Conclusion: Hence, the present brief research indicates the new solid forms of nevirapine with improved dissolution.
Keywords: Cocrystal, nevirapine, surfactant, pH, dissolution
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Submitted: 26 Mar 2020
Revision: 06 Aug 2020
Accepted: 22 Sep 2020
ePublished: 22 Sep 2020
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