Logo-apb
Adv Pharm Bull. 2019;9(3): 374-381.
doi: 10.15171/apb.2019.044
PMID: 31592064
PMCID: PMC6773935
Scopus ID: 85070472014
  Abstract View: 418
  PDF Download: 312

Review Article

5-HIAA as a Potential Biological Marker for Neurological and Psychiatric Disorders

Hridya Jayamohananan 1, Maneesha Kalappurackal Manoj Kumar 1, Aneesh T P 1 * ORCID logo

1 Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, India.

Abstract

Neurological and psychiatric disorders occur in about 6 percent of the global population indicating a significant amount of people suffering from neurological disorder on a varying range in day to day life. On an extensive view, there is a critical requirement for the development of an alternative biomarker for these conditions. The thwart found in developing a biomarker is the difficulty in identifying a serum biomarker as these are mostly limited to the central nervous system (CNS). Serotonin being a neurotransmitter synthesized in the raphe nuclei of the brain could serve as an alternative biomarker. Here, the limitation is that it’s quickly metabolized by the mitochondrial enzyme MAO to 5-hydroxy indole acetic acid (5HIAA). This subsequent metabolite can be used for the analysis of serotonin levels in brain by analysing its concentration in the cerebrospinal fluid (CSF). Many theories suggest that the variations in serotonin level could lead to the development of many neurological and psychiatric disorders like Alzheimer’s disease (AD), schizophrenia, depression and so on. A decreased level is noticed in these patients but this could either be due to decreased production or increased reuptake of serotonin from the neuronal synapses. For instance, we know that a patient with depression shows a significant reduction in the levels of 5HIAA, due to the location of the raphe nuclei within regions of memory and cognition. Similarly, it does shows variation in AD and mild cognitive disorder. Evolving of 5HIAA as a biomarker, could be more delicate and enhanced strategy for monitoring these disorders.
Keywords: Serotonin, Tryptophan, Raphe nuclei, 5-hydroxyindole acetic acid, Neurological functions
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 418

Your browser does not support the canvas element.


PDF Download: 312

Your browser does not support the canvas element.

Submitted: 11 Feb 2019
Revision: 08 Apr 2019
Accepted: 14 Apr 2019
ePublished: 01 Aug 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)