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Adv Pharm Bull. 2020;10(3): 359-369.
doi: 10.34172/apb.2020.044
  Abstract View: 75
  PDF Download: 74

Review Article

A Review on Solid Dispersion and Carriers Used Therein forSolubility Enhancement of Poorly Water Soluble Drugs

Avinash Ramrao Tekade * ORCID logo, Jyoti Narayan Yadav

1 Department of Pharmaceutics, Marathwada Mitra Mandal’s College of Pharmacy, Thergaon, Pune, Maharashtra- 411033, India.

Abstract

A large number of hydrophilic and hydrophobic carriers in pharmaceutical excipients areavailable today which are used for formulation of solid dispersions. Depending on nature ofcarriers the immediate release solid dispersions and/or controlled release solid dispersions canbe formulated. Initially crystalline carriers were used which are transformed into amorphoussolid dispersions with enhanced properties. The carriers used previously were mostly syntheticone. Recent trend towards the use of natural carriers have replaced the use of synthetic carriers.This review is the overview of various synthetic, natural, semisynthetic, modified naturalhydrophilic carriers used for formulation of solid dispersions.
Keywords: Hydrophillic carriers, Mucilage’s, Natural gums, Solid dispersions, Solubility, Solubility enhancement
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Submitted: 25 May 2019
Revision: 26 Dec 2019
Accepted: 23 Jan 2020
ePublished: 11 May 2020
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