Sonia Pandey
1* 
, Farhinbanu Shaikh
1, Arti Gupta
1 , Purnima Tripathi
2, Jitendra Singh Yadav
3 1 Maliba Pharmacy College, Uka tarsadia University, Bardoli Mahuva Road, Surat 394350, Gujarat, India.
2 Department of Pharmaceutics, Bundelkhand University, Jhansi, U.P India.
3 Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umarkh, Surat 394350, Gujarat, India.
*Corresponding Author: Sonia Pandey, Fax: +91 (02625) (255882), Emails: sonia136@rediffmail.com, soniapandeypharm@gmail.com, Email:
sonia136@rediffmail.com
Abstract
Solid lipid nanoparticles (SLNs) are one of the developed technologies for addressing thebioavailability and targeting issues of drug delivery. In this review article, we attempted toincorporate all the essential details of SLNs like various methods of preparation, different modelsof SLNs, updated characterization methods, in vivo behavior (uptake), their applications, routeof administration as well as advancements taken place in the field of delivery of biological drugslike gene vector, new adjuvant for vaccines, protein, and peptide with SLNs. Surface modifiedSLNs hold excellent potential for targeted and controlled drug delivery which is discussed andsummarized. Based on the available data, the future success of SLNs is widened because theycould be easily fabricated with various functionalities which would display enormous potentialfor targeting and diagnosing various diseases. This review would help the budding researchers tofind out the unexplored areas of SLNs with the present discussion that reframes the potential ofSLNs by gathering the various research findings of SLNs in tabular form along with the approvedpatent technologies of SLNs.