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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Review Article

Long Non-coding RNA NEAT1 in Colorectal Cancer: Molecular Mechanisms, Diagnostic Potential, and Resistance to Therapy
Charlotte Jia Qi Tai ORCID, Amar Harris Arifin ORCID, Baskaran Gunasekaran* ORCID, Shamala Salvamani* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46798 | Published on: 2026 Sep 09
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Review Article

Hepatocellular carcinoma therapy and mechanism of action: current perspectives
Sandeep K Bindra ORCID, Sunil K Kumar, Athira Sujathan Nair, Vaishnav K Bhaskar, Krishnadas Madhu Sudan, Lekshmi R Nath, Naseer Maliyakkal, Della Grace Thomas Parambi, Bijo K Mathew* ORCID, Leena K Pappachen* ORCID, Arun Kumar
Adv Pharm Bull. doi: 10.34172/apb.46537 | Published on: 2026 Sep 09
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Research Article

Hypoxia-derived exosomes and RNA-binding protein-enriched fractions modify inflammatory responses in normal microglial cells
Mohammad Khosravi* ORCID, Zohreh Ghotbeddin, Fatemeh Ghasemi-BabaAhmadi
Adv Pharm Bull. doi: 10.34172/apb.47409 | Published on: 2026 Sep 06
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Research Article

Niosomal Co-delivery of Curcumin and Silibinin Enhances Synergistic Anticancer Activity Against Colorectal Cancer Cells
Fatemeh Toroghi ORCID, Davood Jafari, Rezvan Najafi, Ali Mahdavinezhad, Saeid Afshar, Nosratollah Zarghami* ORCID, Raziyeh Amini
Adv Pharm Bull. doi: 10.34172/apb.47534 | Published on: 2026 Sep 05
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Research Article

Study the Synergistic Effect of Combination Therapy Containing Temozolomide and N-Acetylcysteine Loaded Polymeric Micelles in Cancer Treatment
Mohammed Salah Ahmed Teiama* ORCID, wedad sakran ORCID, Fares Masry ORCID, Sara Ahmed Abdel Gaber ORCID, Raghda abd el moneum Ali ORCID
Adv Pharm Bull. doi: 10.34172/apb.47566 | Published on: 2026 Sep 05
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Review Article

Targeting the Immunosuppressive Microenvironment in Colorectal Cancer: Pharmacological and Nanomedicine Strategies

Qamar Abuhassan ORCID, Usamah Sayed, Pareshkumar N. Patel, S. Renuka Jyothi, Gunjan Singh, Priya Priyadarshini Nayak* ORCID, Vimal Arora, Gulnora Shakhmurova
Adv Pharm Bull. doi: 10.34172/apb.47456 | Published on: 2026 Sep 05
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Research Article

Deciphering Food-Disease Relationships Through Molecular Networks in Breast Cancer
Zahra Fathifar ORCID, Leila R. Kalankesh ORCID, Fatemeh Sadeghi-Ghyassi ORCID, Yadollah Omidi ORCID, Alireza Ostadrahimi ORCID, Reza Ferdousi* ORCID
Adv Pharm Bull. doi: 10.34172/apb.47157 | Published on: 2026 Sep 05
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Systematic Review

The effects of combination therapy with Glucagon-like peptide 1 receptor agonists and sodium-glucose co-transporters 2 inhibitors on cardiometabolic indices: A GRADE assessed systematic review and meta-analysis
Seyyed Mostafa Arabi ORCID, Iman Rahnama, Mahsa Malek Ahmadi, Mohtaram Hashemi, Mohammad Mahdi Marvi, Sana Mahdian, Leila Sadat Bahrami, Amirhossein Sahebkar* ORCID
Adv Pharm Bull. doi: 10.34172/apb.43187 | Published on: 2026 Sep 03
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Review Article

RNA Nanotechnology for Reversal of Melanoma Immunotherapy Resistance
Mojtaba Tarin ORCID, Mahsa Akbari Oryani, Sareh Etemad, Amirhossein Ebadi, Hossein Javid, Mehdi Karimi-Shahri* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46274 | Published on: 2026 Aug 31
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Research Article

Development of Cationic Dextran Nanoparticles via Reductive Amination: Enhanced Cellular Uptake and Low Cytotoxicity in Gene Transfection
Kianoosh Karami ORCID, Seyed Sepehr Uroomiye ORCID, Katayoun Derakhshandeh* ORCID, Fatemeh Nouri ORCID, Gholamabbas Chehardoli ORCID, Reza Haji Hosseini ORCID
Adv Pharm Bull. doi: 10.34172/apb.46469 | Published on: 2026 Aug 31
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Research Article

Transethosomal diflunisal gel: Physicochemical characterization, skin permeation, and antinociceptive activity in mice
Indah Aprianti* ORCID, Iskandarsyah Iskandarsyah ORCID, Heri Setiawan ORCID
Adv Pharm Bull. doi: 10.34172/apb.47449 | Published on: 2026 Aug 31
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Letter to Editor

Could RAS Inhibition Create a Transient Window for Tumor-Antigen Cross-Presentation in Pancreatic Cancer?
Maher Monir Akl* ORCID, Abdelrahman Ahya M. Ali ORCID, Khalid Saeed Sadoon Hamad ORCID, Amr Ahmed ORCID
Adv Pharm Bull. doi: 10.34172/apb.47510 | Published on: 2026 Aug 26
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Letter to Editor

Could Alpha-Lipoic Acid Improve Arteriovenous Fistula Maturation? A Mechanistic Hypothesis
Zahra Nazari Taloki* ORCID
Adv Pharm Bull. doi: 10.34172/apb.47500 | Published on: 2026 Aug 26
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Research Article

Investigating the Gastroprotective Impact of Sitagliptin on Ethanol-Induced Gastric Ulcers in Rats: Insights into the NO/cGMP/KATP Signaling Pathway
Parnian Mohammadzadeh ORCID, Behnam Ghorbanzadeh* ORCID, Mohammad Seydabadi, ladan kharaz ORCID, Tarang Taghvaei Arabi, Fereshteh Beigom Talebpour Amiri, Mohammad Shokati sayyad, Sara Bayat, Gholamreza Houshmand* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46781 | Published on: 2026 Aug 09
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Research Article

Targeting p53/p21 Signaling: Linarin as a Novel Modulator of 5-FU Sensitization in Colorectal Cancer
Amir Valizadeh ORCID, Mohammad Rahmati-Yamchi ORCID, Alireza Ali Hemmati ORCID, Mohammad Ebrahimnejad ORCID, Ali Yousefzadeh ORCID, Mehran Molavand ORCID, Bahman Yousefi* ORCID
Adv Pharm Bull. doi: 10.34172/apb.47354 | Published on: 2026 Aug 09
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Review Article

Ultrasound-Based Nanocarriers: Advances and Applications in Tumor Therapy
yaqing gao ORCID, yixuan wang, kexin meng, fengjing fan, fei li, yongjun liu*, bei wang* ORCID
Adv Pharm Bull. doi: 10.34172/apb.47309 | Published on: 2026 Aug 09
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Review Article

The Multifaceted Role of MAPK/ERK Signaling Pathways in Cancer Drug Resistance: An Update
Mehran Molavand* ORCID, Amir Valizadeh ORCID, Maryam Majidinia ORCID, Bahman Yousefi* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46570 | Published on: 2026 Aug 09
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Systematic Review

Cannabinoid receptors and neuroinflammation in ischemic stroke: A systematic review
Esmaeil Imani-Almas, Maryam Azarfarin, Nayer Seyfizadeh, Hanieh Salehi-Pourmehr, Sara Salatin* ORCID, Samin Hamidi
Adv Pharm Bull. doi: 10.34172/apb.46785 | Published on: 2026 Jul 25
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Systematic Review

Effects of probiotics, prebiotics and synbiotics on gut microbiota and lipid profiles in patients with dyslipidaemia: A systematic review
Mohammad Amirul Izzan Amran ORCID, Siong Meng Lim* ORCID, Chin Fen Neoh ORCID, Abu Bakar Abdul Majeed ORCID, Anis Safura Ramli ORCID, Kalavathy Ramasamy* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46477 | Published on: 2026 Jul 25
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Research Article

“Dual-loaded curcumin-metformin niosomes: physicochemical characterization and in vitro activity in colorectal and pancreatic cancer cells”
Aboalhasan Al-Yaqoobi, Zainab Lafi* ORCID, Sina Matalqah ORCID, Anas Abed, Sara Almahamid
Adv Pharm Bull. doi: 10.34172/apb.46556 | Published on: 2026 Jul 18
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Review Article

Next-Generation mRNA Cancer Vaccines: Integrating Innovative Delivery Systems, Personalized Antigen Discovery, and Future Clinical Strategies
Maryam Mashhadi Abolghasem Shirazi* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46663 | Published on: 2026 Jul 14
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Research Article

Redox-mediated sensitization of melanoma cells to Vemurafenib by cold atmospheric plasma: A molecular insight into apoptotic and autophagic regulation
Zahra Yazdani ORCID, Farshad Sohbatzadeh, Saeid Abediankenari, Monireh Golpour, Sadegh Fattahi, Alireza Rafiei* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46838 | Published on: 2026 Jul 12
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Research Article

Development of a flow cytometric immunoassay using recombinant vascular endothelial growth factor (VEGF)-functionalized poly(ε-caprolactone) microbeads for bevacizumab quantification
Negar Namaei-Ghasemnia ORCID, Mohammad Rabiee* ORCID, Fatemeh Davami* ORCID, Yeganeh Talebkhan-Garoosi ORCID, Mohamad Ghorbani ORCID
Adv Pharm Bull. doi: 10.34172/apb.46777 | Published on: 2026 Jul 12
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Research Article

Anti-Apoptotic Effects of Sericin in Lumbar Canal Stenosis-Induced Underactive Bladder Model
Sakineh Hajebrahimi ORCID, Nasrin Abolhasanpour ORCID, Hadi Mostafaei, Leila Hosseini, Fateme Tahmasbi, Javad Mahmoudi* ORCID, Hanieh Salehi-Pourmehr* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46989 | Published on: 2026 Jul 11
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Research Article

Protodioscin Restores Ovarian Function and Suppresses p53–Bax/Bcl-2–Mediated Apoptosis in a Doxorubicin-Induced Model of Ovarian toxicity
Amoura M. Abou-El-Naga ORCID, Aya M. Abd-Elhady, Mohamed E. Abdraboh ORCID, Yasmin M. Tag, Maher Monir Akl* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46593 | Published on: 2026 Jul 11
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Research Article

Development of Spray-Dried Enteric Omeprazole Microparticles Using O-Carboxymethyl Chitosan and Eudragit® S100: Central composite Design Optimization and In Vitro-In Vivo evaluation
Hamid Reza Arabloo ORCID, Homa Faghihi ORCID, Melika Kiani ORCID, Fatemeh Khonsari ORCID, Mahdi Gholami, Fatemeh Atyabi* ORCID
Adv Pharm Bull. doi: 10.34172/apb.47194 | Published on: 2026 Jul 01
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Research Article

Effects of Ketogenic Diet on Neuropeptides (Kisspeptin and Phoenixin-14) in Obese Polycystic Ovarian Syndrome

Talib Hussein Abdullah* ORCID, Diana Hussein Abdullah, Malik Musa Sultan ORCID
Adv Pharm Bull. doi: 10.34172/apb.47249 | Published on: 2026 Jul 01
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Research Article

pH-Sensitive Folate-Targeted Liposomal Vitamin D Reprograms EZH2/STAT3 Axis and Induces Apoptosis, ROS, and Autophagy in MCF-7 Breast Cancer Cells
Soheil Abbaspour-Ravasjani ORCID, Rahim Shahvalizadeh ORCID, Malahat Safavi ORCID, Mina A frashteh Nour ORCID, Mahdi Talebi ORCID, Maryam Mohammadi, Hamed Hamishehkar* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46791 | Published on: 2026 Jul 01
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Review Article

Radiotheranostics and the Future of Cancer Therapy: Harnessing Combination Strategies and AI
Ayad H. Hasan ORCID, Mohammadreza Azimi ORCID, Tola Abdulsattar Faraj, Nazila Biglari, Nazanin Musapour, Sadaf safaei ORCID, Houman Torabian Basmen ORCID, Soran K. Najmaldin, Zahrah Mohammed Maghdid, Mostafa kashani* ORCID, Vesal Firoozi* ORCID
Adv Pharm Bull. doi: 10.34172/apb.47174 | Published on: 2026 Jul 01
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Review Article

Lipid-Based Nanocarriers for Acne Treatment: Current Progress and Clinical Feasibility
Ayda Rajabi ORCID, Azizeh Rahmani Del Bakhshayesh, Leila Hosseini, Azizeh Farshbaf-khalili, Halimeh Amirazad, Amélia C. F. Vieira, Soraya Babaie* ORCID, Ana Cláudia Paiva-Santos*
Adv Pharm Bull. doi: 10.34172/apb.47085 | Published on: 2026 Jul 01
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Research Article

Autophagy modulation influenced the spermatogenesis in rodent testicular organoids and diabetic condition
Shadi Atazadeh ORCID, Maryam Hasan Sadeh, Farah Farokhi, Shahin Ahmadian, Sepideh Saghati, Fereshteh Valipour, Amir Fattahi, Amin Tamadon, Reza Rahbarghazi, Mahdi Mahdipour* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46240 | Published on: 2026 Jun 29
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Research Article

Exploring Siglec-7 expression and apoptosis rates in platelet concentrates under various storage conditions
Asra Amelirad ORCID, Davoud Pashoutan Sarvar ORCID, Parvin Akbarzadehlaleh ORCID, Karim Shamsasenjan* ORCID
Adv Pharm Bull. doi: 10.34172/apb.47163 | Published on: 2026 Jun 29
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Mini Review

Development of Cloned B Cell Populations as Immunotherapeutic Agents Against Myc Carcinogenic Proteins
Manisha S Lalan* ORCID, Sushrut S Joshi, chitrali S Talele, Guno Sindhu Chakraborthy, Sachin Mali
Adv Pharm Bull. doi: 10.34172/apb.46527 | Published on: 2026 Jun 29
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Research Article

Investigating the Radioprotective Properties of C60 Fullerene Nanoparticles: Effects on Adipose-Derived Stem Cell Viability and Inflammatory Markers
Golnoosh Goodarzi Fard ORCID, Arash Abdolmaleki* ORCID, Asadollah Asadi, Farhad Zolfagharpour, Ezzat Nourizadeh, Aida Nahumi, Hussein A. Ghanimi
Adv Pharm Bull. doi: 10.34172/apb.46954 | Published on: 2026 Jun 29
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Research Article

Comparative Analysis of MAR and Terminator Elements in Controlling Stable EPO Expression in CHO-K1 Cells
Fatemeh Jalali* ORCID, Shahriyar Abdoli, Fatemeh Shamsabadi, Ahad Yamchi, Anvarsadat Kianmehr, Majid Shahbazi* ORCID
Adv Pharm Bull. doi: 10.34172/apb.45955 | Published on: 2026 Jun 29
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Research Article

Royal Jelly-Loaded LDH Nanostructures: A Novel Topical Therapy for Atopic Dermatitis via Inflammasome Suppression in Mice
Fardin Khajepour ORCID, Mehdi Ranjbar, Merat Mahmoodi, Nasrin Bazargan, Fatemeh Mohammadi Henjeroei, Muhammad Hossein Ashoub, Reza Nosratabadi ORCID
Adv Pharm Bull. doi: 10.34172/apb.46710 | Published on: 2026 Jun 29
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Review Article

Interplay between endolysosomal calcium signalling, EMT, and autophagy in colorectal cancer (CRC): Implications for metastasis and therapeutic strategies.
Nur Aqilah Nadhirah Affendie ORCID, Nurul Syahmin Ab Aziz, Siti Yusrina Nadihah Jamaludin ORCID, Normala Abd Latip ORCID, Aisyah Hasyila Jahidin* ORCID
Adv Pharm Bull. doi: 10.34172/apb.45688 | Published on: 2026 Jun 29
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Research Article

Sericin improves cognitive outcomes in a mouse model of cerebral ischemia: The role of Blood-Brain Barrier disruption and edema
Leila Hosseini ORCID, Seyed Mehdi Vatandoust, Narmin Farazi, Amir Pasokh, Saeed Sadigh-Eteghad, Mohammad Farzipour, Fereshteh Farajdokht, Alireza Mohajjel Nayebi, Ali Hassanzadeh, Javad Mahmoudi ORCID
Adv Pharm Bull. doi: 10.34172/apb.46668 | Published on: 2026 Jun 29
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Research Article

Inducing collagen synthesis by a combination of an integrin receptor-stimulating collagen-based peptide and Chlorella vulgaris extract
Marjan Gholami ORCID, Seyed Shahriar Arab, Mehrdad Behmanesh* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46552 | Published on: 2026 Jun 29
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Mini Review

Wound Healing and Nanotechnology: Recent Advances and Future Perspectives
Solmaz Ghaffari* ORCID, maryam Hassan ORCID
Adv Pharm Bull. doi: 10.34172/apb.47125 | Published on: 2026 Jun 28
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Research Article

Restoration of the PINK1/Parkin/PGC-1α axis by Liraglutide and Pravastatin co-therapy mitigates Doxorubicin-induced cardiotoxicity
Nada Monir Emad ORCID, Omneya Galal ORCID, Azza Said Awad ORCID, Hala Fahmy Zaki ORCID, Mona Magdy Saber* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46963 | Published on: 2026 Jun 23
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Research Article

Coenzyme Q10 as a promising supplement for traumatic brain injury: a randomized, double-blind, placebo-controlled study
Mahdi Saghiriganjeh ORCID, Bahareh Hakiminia* ORCID, Bahador Bagheri ORCID, Keyhan Poorali ORCID, Ehsan Hosseinzadeh ORCID, Sara Salarian ORCID
Adv Pharm Bull. doi: 10.34172/apb.47049 | Published on: 2026 Jun 23
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Review Article

Chlorotoxin: A Scorpion Venom-Derived Peptide for Targeted Glioma Therapy and Imaging
Majid Jafari-Sabet* ORCID, Mohammad-Sadegh Lotfi
Adv Pharm Bull. doi: 10.34172/apb.47159 | Published on: 2026 Jun 22
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Research Article

The Effect of Wheat Adventitious Root and Callus Extracts on Protecting Skin Fibroblast Cells against Ultraviolet B
Azam Salmasi, Hamed Hamishehkar* ORCID, Sajjad Sedaghat, Parviz Abroumand Azar
Adv Pharm Bull. doi: 10.34172/apb.47136 | Published on: 2026 Jun 17
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Original Article

Combination therapy of cisplatin and naturally induced exosomes from treated HeLa cells: A novel drug-free strategy for cervical cancer treatment
Sanaz Aghajani ORCID, Nasim Vousooghi, Abbas Hajifathali, Iman Seyhoun, Javad Verdi* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46428 | Published on: 2026 Jun 15
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Letter to Editor

Gut microbiome influences the efficacy of neuropsychiatric drugs
Anjal Mohamed Ageel ORCID, Kannan Subbaram* ORCID, Sheeza Ali ORCID, Queen Alice Arul ORCID
Adv Pharm Bull. doi: 10.34172/apb.47093 | Published on: 2026 Jun 01
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Systematic Review

Molecular And Clinical Significance of PDGFR Family in Papillary Thyroid Cancer: A Systematic Review
Atiyeh Dabouian ORCID, Roya Ghafoury, Mahboobeh Nazari, Omolbanin Asadi Ghadikolaeidi, Mohammad E. Khamseh*, sara cheraghi* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46975 | Published on: 2026 May 24
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Research Article

Application of electrospun polycaprolactone/gelatin/layered double hydroxide/hymercromone in the death of melanoma cancer cells
fatemeh morad ORCID, tahereh foroutan* ORCID, seyedeh sara shafiei
Adv Pharm Bull. doi: 10.34172/apb.46964 | Published on: 2026 May 24
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Review Article

PLGA based “Lipid-Polymer Hybrid Nanoparticles”: A Convergent Platform of Active and Targeted Drug Delivery
Rajlaxmi Patro ORCID, Ch. Niranjan Patra, Subrata Mallick* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46136 | Published on: 2026 May 23
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Letter to Editor

Circulating Exosomal Cargoes and Platelet-Derived Factors May Contribute to Organ Failure in Sepsis

Muhammad Esa* ORCID, Sunisa Kaewpaiboon, Tawseef Ahmad, Muhammad Khan, Asad Ur Rahman*, Teerapol Srichana* ORCID
Adv Pharm Bull. doi: 10.34172/apb.47033 | Published on: 2026 May 19
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Letter to Editor

miR-34a in PFIC: Hypothesized Links to Dyslipidemia and Liver Regeneration
AMR AHMED EL-ARABEY* ORCID, Kapil K. Upadhyay
Adv Pharm Bull. doi: 10.34172/apb.46776 | Published on: 2026 May 19
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Research Article

Neurogenic Effect of Hypoxia-Conditioned UC-MSC Secretome from Macaca fascicularis in an In Vitro Stroke Model
Gita Serafika Shannon ORCID, Amarila Malik* ORCID, Ratih Rinendyaputri* ORCID, Sela Septima Mariya ORCID, Sunarno Sunarno ORCID, Rachmawati Noverina, Putri Retno Intan ORCID, Wireni Ayuningtyas, Fathul Huda ORCID, Ahmad Faried ORCID
Adv Pharm Bull. doi: 10.34172/apb.46137 | Published on: 2026 May 19
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Research Article

Optimization, ex-vivo penetration and in-vivo evaluation of PEGylated nanostructured lipid carriers of olmesartan medoxomil to enhance transdermal delivery
rofida albash* ORCID, Aly A. Abdelbary, Hanan refai, mohamed nabarawi
Adv Pharm Bull. doi: 10.34172/apb.46458 | Published on: 2026 May 19
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Research Article

ACKR3 upregulation under hyperglycemia associates with endothelial dysfunction
Seyedeh Zohreh Azarshin ORCID, Zahra Abedi Kich ORCID, Shahram Rabbani ORCID, Mohammad Ali Boroumand ORCID, Mousa Golalizadeh Lahi ORCID, Mehrdad Behmanesh* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46517 | Published on: 2026 May 10
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Research Article

ALA nanoemulsion prepared by microfluidic for ocular delivery: In-vitro and in-vivo studies
Javad Behmadi ORCID, Amiremad Kheirieh, Asma Mahmoudi, Mojtaba Abrishami, Seyed Ali Mousavi Shaegh, Amirhossein Abbasi, Bizhan Malaekeh-Nikouei* ORCID
Adv Pharm Bull. doi: 10.34172/apb.46273 | Published on: 2026 May 09
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Research Article

Smart Delivery of Resveratrol to Glioblastoma Cells Using Hybrid Nanoparticles: Cytotoxic, Uptake, and Pharmacokinetic Insights
SWATI DEVENDRA RAYSING* ORCID, Ashish Prakash Gorle ORCID
Adv Pharm Bull. doi: 10.34172/apb.46117 | Published on: 2026 May 09
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